23:00 | position 1Cruz Azul | Home win (favourite), market odds: 1.98 | Cruz Azul vs Mazatlán: 2FTFinished0HT 2–0 | Away win (outsider), market odds: 4.03 |  Mazatlán | LDWWDL | |
23:00 | position 10Pérez Zeledón | Home win (outsider), market odds: 2.65 | Pérez Zeledón vs Guadalupe: 2FTFinished1HT 0–1 | Away win (favourite), market odds: 2.59 |  Guadalupe | WLLLLW | |
23:00 | position 1Peñarol | Home win (favourite), market odds: 1.34 | Peñarol vs Rentistas: 2FTFinished2HT 0–1 | Away win (outsider), market odds: 10.84 |  Rentistas | WLDLW | |
23:00 | position 3Deportivo La Guaira | Home win (favourite), market odds: 1.60 | Deportivo La Guaira vs UCV: 0FTFinished1HT 0–0 | Away win (outsider), market odds: 4.90 |  UCVposition 4 | WDD | |
23:00 | position 8FC Cincinnati II | —No pre-match price | FC Cincinnati II vs Chicago Fire II: 0FTFinished2HT 0–0 | —No pre-match price |  Chicago Fire II | DL | |
23:00 | Guastatoya | Home win (favourite), market odds: 1.49 | Guastatoya vs Iztapa: 3FTFinished0HT 2–0 | Away win (outsider), market odds: 6.05 |  Iztapa | LWDLDW | |
23:00 | position 7Olancho | —No pre-match price | Olancho vs Marathón: 2FTFinished3HT 1–1 | —No pre-match price |  Marathónposition 3 | WWLDDL | |
23:00 | Huracanes Izcalli | Home win (favourite), market odds: 2.25 | Huracanes Izcalli vs Alebrijes de Oaxaca II: 1FTFinished3 | Away win (outsider), market odds: 2.50 |  Alebrijes de Oaxaca II | WLLDWD | |
23:00 | Deportiva Venados | —No pre-match price | Deportiva Venados vs Inter Playa del Carmen: 2FTFinished1HT 1–1 | —No pre-match price |  Inter Playa del Carmen | WLWDW | |
23:00 | position 6Sport Sébaco | —No pre-match price | Sport Sébaco vs Walter Ferretti: 1FTFinished1HT 0–1 | —No pre-match price |  Walter Ferrettiposition 5 | DLWW | |
23:00 | Diriangén U20 | —No pre-match price | Diriangén U20 vs UNAN Managua U20: 1FTFinished0HT 1–0 | —No pre-match price |  UNAN Managua U20 | WDWDL | |
23:05 | position 19Jaguares de Córdoba | Home win (outsider), market odds: 3.69 | Jaguares de Córdoba vs Atlético Nacional: 0FTFinished1HT 0–0 | Away win (favourite), market odds: 2.14 |  Atlético Nacionalposition 1 | LDLDW | |
23:15 | Jorge Wilstermann | Home win (favourite), market odds: 2.57 | Jorge Wilstermann vs The Strongest: 0FTFinished3HT 0–2 | Away win (outsider), market odds: 2.62 |  The Strongestposition 3 | DWDWWDLW | |
23:30 | position 5Aucas | Home win (favourite), market odds: 2.13 | Aucas vs Emelec: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 3.49 |  Emelecposition 10 | WWWW | |
| 23:30 | position 8Saltillo | Home win (favourite), market odds: 2.05 | Saltillo vs Lobos ULMX: 3FTFinished1HT 0–1 | Away win (outsider), market odds: 3.00 |  Lobos ULMX | WDWWL | |
