01:00 | position 11Pumas UNAM | Home win (favourite), market odds: 1.88 | Pumas UNAM vs Juárez: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 4.41 |  Juárezposition 18 | DLDWLDWDLD | |
| 01:00 | position 9León | Home win (favourite), market odds: 1.55 | León vs Puebla: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 6.07 |  Pueblaposition 14 | DLLLWDLLLL | |
01:00 | position 3Independiente | —No pre-match price | Independiente vs Veraguas United: 2FTFinished3HT 2–0 | —No pre-match price |  Veraguas Unitedposition 2 | LWDDWLLWLW | |
01:00 | position 10Operário PR | Home win (favourite), market odds: 2.65 | Operário PR vs Goiás: 1FTFinished2HT 0–0 | Away win (outsider), market odds: 3.30 |  Goiásposition 7 | WDDWLDWDDD | |
01:00 | Tigres de Álica | —No pre-match price | Tigres de Álica vs Tritons Vallarta: 2FTFinished1HT 1–0 | —No pre-match price |  Tritons Vallarta | WWLLWWDLWD | |
| 01:00 | position 4Mineros de Fresnillo | —No pre-match price | Mineros de Fresnillo vs UA Zacatecas: 0FTFinished2HT 0–0 | —No pre-match price |  UA Zacatecas | LWLLLLLLWD | |
01:00 | position 1Carolina Ascent | —No pre-match price | Carolina Ascent vs Brooklyn: 5FTFinished0HT 1–0 | —No pre-match price |  Brooklynposition 6 | WWWLWLDDLL | |
| 01:00 | position 7Tampa Bay Sun | —No pre-match price | Tampa Bay Sun vs Lexington: 4FTFinished1HT 3–0 | —No pre-match price |  Lexingtonposition 4 | WDLWDLLWDL | |
01:00 | position 8Naples | —No pre-match price | Naples vs Richmond Kickers: 2FTFinished1HT 2–1 | —No pre-match price |  Richmond Kickersposition 17 | WWDWWWLWLL | |
01:00 | Atlético Huila | Home win (favourite), market odds: 2.14 | Atlético Huila vs Internacional Palmira: 1FTFinished0HT 1–0 | Away win (outsider), market odds: 4.16 |  Internacional Palmiraposition 14 | WWDWWWWWLW | |
01:00 | position 4Lexington | Home win (favourite), market odds: 1.83 | Lexington vs Las Vegas Lights: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 3.95 |  Las Vegas Lightsposition 11 | LLLDDWDLWL | |
01:00 | Atlante | Home win (favourite), market odds: 2.37 | Atlante vs Mineros de Zacatecas: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 2.93 |  Mineros de Zacatecasposition 10 | LWDWWDLWWW | |
01:00 | Comunicaciones | —No pre-match price | Comunicaciones vs Achuapa: 1FTFinished0HT 0–0 | —No pre-match price |  Achuapa | WWDLLLLDLW | |
01:00 | position 8Sarmiento Resistencia | —No pre-match price | Sarmiento Resistencia vs Sol de América: 1FTFinished0HT 0–0 | —No pre-match price |  Sol de Américaposition 3 | LLLWLWDWLW | |
01:00 | Police | —No pre-match price | Police vs Prison Service: 3FTFinished0HT 0–0 | —No pre-match price |  Prison Service | LWWWWWWLLL | |
01:00 | Broki | —No pre-match price | Broki vs Voorwaarts: 0FTFinished6HT 0–1 | —No pre-match price |  Voorwaarts | WLLLLWLLLW | |
01:00 | position 7Municipal Jalapa | —No pre-match price | Municipal Jalapa vs Diriangén: 2FTFinished2HT 1–1 | —No pre-match price |  Diriangénposition 2 | DLLLWWLLDL | |
01:15 | position 7Olancho | Home win (favourite), market odds: 2.30 | Olancho vs Marathón: 0FTFinished1HT 0–0 | Away win (outsider), market odds: 3.10 |  Marathónposition 4 | DWWLLWWDWW | |
01:20 | position 18Deportivo Pasto | Home win (favourite), market odds: 2.45 | Deportivo Pasto vs Junior: 3FTFinished3HT 3–1 | Away win (outsider), market odds: 3.51 |  Juniorposition 17 | DDDWWWWWWW | |
01:30 | position 14D.C. United | Home win (favourite), market odds: 2.32 | D.C. United vs Cincinnati: 0FTFinished1HT 0–1 | Away win (outsider), market odds: 3.05 |  Cincinnatiposition 9 | LLLDWWWDLL | |
| 01:30 | position 11New York City | Home win (favourite), market odds: 2.05 | New York City vs Philadelphia Union: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 3.63 |  Philadelphia Unionposition 6 | LLDWWDLWLW | |
| 01:30 | position 1Vancouver Whitecaps | Home win (favourite), market odds: 1.94 | Vancouver Whitecaps vs Austin: 5FTFinished1HT 2–0 | Away win (outsider), market odds: 4.16 |  Austinposition 14 | DWDDLDWWWL | |
| 01:30 | position 15Montréal | Home win (favourite), market odds: 2.46 | Montréal vs Charlotte: 0FTFinished1HT 0–1 | Away win (outsider), market odds: 3.12 |  Charlotteposition 5 | LDLDLWLWWL | |
01:30 | position 3Belgrano | Home win (outsider), market odds: 3.39 | Belgrano vs Boca Juniors: 1FTFinished3HT 0–1 | Away win (favourite), market odds: 2.45 |  Boca Juniorsposition 5 | WDDDLWLWWW | |
| 01:30 | position 8Fort Lauderdale United | —No pre-match price | Fort Lauderdale United vs DC Power: 1FTFinished1HT 0–0 | —No pre-match price |  DC Powerposition 2 | LDWDWLLDLL | |
| 01:30 | Tormenta | —No pre-match price | Tormenta vs Portland Hearts of Pine: 2FTFinished1HT 1–0 | —No pre-match price |  Portland Hearts of Pineposition 14 | DWLWWDDDWL | |
| 01:30 | position 2Charleston Battery | Home win (favourite), market odds: 1.80 | Charleston Battery vs Pittsburgh Riverhounds: 2FTFinished1HT 0–1 | Away win (outsider), market odds: 4.82 |  Pittsburgh Riverhoundsposition 5 | WLWLWWWWLD | |
| 01:30 | position 1Tampa Bay Rowdies | Home win (favourite), market odds: 1.85 | Tampa Bay Rowdies vs Loudoun United: 1FTFinished2HT 0–0 | Away win (outsider), market odds: 4.33 |  Loudoun Unitedposition 10 | LWWLLWWWLW | |
01:30 | position 8Seattle Reign | Home win (outsider), market odds: 5.02 | Seattle Reign vs Orlando Pride: 0FTFinished1HT 0–1 | Away win (favourite), market odds: 1.65 |  Orlando Prideposition 11 | LWWDLWWWDW | |
