22:00 | position 15CF Montreal | Home win (outsider), Pinnacle: 4.43 | CF Montreal vs Vancouver Whitecaps: Not started | Away win (favourite), Pinnacle: 1.65 |  Vancouver Whitecapsposition 1 | DLLDDWWLWD | |
| 22:00 | position 4Chicago Fire | Home win (favourite), Pinnacle: 1.98 | Chicago Fire vs Columbus Crew: Not started | Away win (outsider), Pinnacle: 3.34 |  Columbus Crewposition 8 | WDWLLWWWDW | |
| 22:00 | position 14DC United | Home win (outsider), Pinnacle: 3.04 | DC United vs New York City: Not started | Away win (favourite), Pinnacle: 2.24 |  New York Cityposition 11 | LLLLLDWDDL | |
| 22:00 | position 7FC Cincinnati | Home win (outsider), Pinnacle: 2.58 | FC Cincinnati vs Nashville SC: Not started | Away win (favourite), Pinnacle: 2.47 |  Nashville SCposition 1 | WDWWLWDWDW | |
| 22:00 | position 2Inter Miami | Home win (favourite), Pinnacle: 1.38 | Inter Miami vs Charlotte: Not started | Away win (outsider), Pinnacle: 6.40 |  Charlotteposition 5 | WDLWWWWLDL | |
| 22:00 | position 10New York Red Bulls | Home win (favourite), Pinnacle: 1.85 | New York Red Bulls vs Atlanta Utd: Not started | Away win (outsider), Pinnacle: 3.59 |  Atlanta Utdposition 13 | LLWLLWLLLW | |
| 22:00 | position 9Orlando City | Home win (favourite), Pinnacle: 1.96 | Orlando City vs New England Revolution: Not started | Away win (outsider), Pinnacle: 3.23 |  New England Revolutionposition 3 | LDDWDLWWWW | |
| 22:00 | position 6Philadelphia Union | Home win (favourite), Pinnacle: 1.43 | Philadelphia Union vs Toronto FC: Not started | Away win (outsider), Pinnacle: 5.92 |  Toronto FCposition 12 | LDLDWLWLWD | |
22:00 | position 4Deportivo Universitario | Home win (favourite), Pinnacle: 2.24 | Deportivo Universitario vs Veraguas: Not started | Away win (outsider), Pinnacle: 2.98 |  Veraguasposition 2 | WLLLWWWLWD | |
| 22:00 | position 5Herrera | —No pre-match price | Herrera vs Independiente: Not started | —No pre-match price |  Independienteposition 3 | LLWWLWWWDL | |
| 22:00 | position 1San Francisco | —No pre-match price | San Francisco vs Union Cocle: Not started | —No pre-match price |  Union Cocleposition 6 | LWWLWLLLLL | |
22:00 | Atletico-MG | Home win (favourite), Pinnacle: 1.60 | Atletico-MG vs Gremio: Not started | Away win (outsider), Pinnacle: 5.24 |  Gremio | LLLLLLWWWL | |
22:00 | Deportivo Mixco | Home win (favourite), Pinnacle: 1.41 | Deportivo Mixco vs Deportivo San Pedro: Not started | Away win (outsider), Pinnacle: 7.36 |  Deportivo San Pedro | LDWDWWLDLD | |
22:00 | position 6Platense Municipal | Home win (favourite), Pinnacle: 2.02 | Platense Municipal vs Cacahuatique: Not started | Away win (outsider), Pinnacle: 3.65 |  Cacahuatiqueposition 10 | DDWWWWDDLL | |
22:00 | position 9Deportes Rengo | —No pre-match price | Deportes Rengo vs Real San Joaquin: Not started | —No pre-match price |  Real San Joaquinposition 14 | LLWWDDWLLD | |
22:00 | position 12Juticalpa | Home win (outsider), bet365: 3.75 | Juticalpa vs Estrella Roja: Not started | Away win (favourite), bet365: 1.75 |  Estrella Rojaposition 7 | LLLLLLWDWL | |
22:00 | position 1Cavalry | Home win (favourite), Pinnacle: 1.81 | Cavalry vs Supra du Quebec: Not started | Away win (outsider), Pinnacle: 3.66 |  Supra du Quebecposition 4 | LWWDLWWWDW | |
22:00 | Cruz de Chalpon | —No pre-match price | Cruz de Chalpon vs Cajabamba: Not started | —No pre-match price |  Cajabamba | —— | |
| 22:00 | Deportivo El Inca | —No pre-match price | Deportivo El Inca vs Tiro: Not started | —No pre-match price |  Tiro | LDDWW— | |
| 22:00 | Juliaca | —No pre-match price | Juliaca vs Juventud Palmeiras: Not started | —No pre-match price |  Juventud Palmeiras | —LLDLD | |
| 22:00 | Sport Huaja | —No pre-match price | Sport Huaja vs Leones de Anccaca: Not started | —No pre-match price |  Leones de Anccaca | —— | |
22:00 | Greenbay Hoppers | —No pre-match price | Greenbay Hoppers vs Garden Stars: Not started | —No pre-match price |  Garden Stars | LWLLLWWWLW | |
22:05 | position 9Once Caldas | Home win (favourite), Pinnacle: 1.76 | Once Caldas vs Aguilas: Not started | Away win (outsider), Pinnacle: 4.60 |  Aguilasposition 8 | WWDDWWWLWD | |
22:15 | position 2Always Ready | Home win (favourite), bet365: 1.08 | Always Ready vs Academia del Balompie: Not started | Away win (outsider), bet365: 19.00 |  Academia del Balompieposition 16 | WWWDLLLLLL | |
22:30 | position 9Leones del Norte | Home win (favourite), Pinnacle: 1.77 | Leones del Norte vs Guayaquil City: Not started | Away win (outsider), Pinnacle: 4.66 |  Guayaquil Cityposition 8 | WWLLDDWLWD | |
22:30 | Celaya 2 | —No pre-match price | Celaya 2 vs Ayense: Not started | —No pre-match price |  Ayense | LDWWDWDLLL | |
22:30 | Pioneros | —No pre-match price | Pioneros vs Reboceros de La Piedad: Not started | —No pre-match price |  Reboceros de La Piedad | LDDWWLDLWD | |
22:30 | position 4Monagas | Home win (outsider), Pinnacle: 3.79 | Monagas vs Dep. Tachira: Not started | Away win (favourite), Pinnacle: 2.06 |  Dep. Tachiraposition 2 | LWLLDWWWWD | |
| 22:30 | position 2Caracas | Home win (outsider), Pinnacle: 3.17 | Caracas vs Puerto Cabello: Not started | Away win (favourite), Pinnacle: 2.33 |  Puerto Cabelloposition 1 | WLWLDLLLWW | |
