22:00 | position 16Alianza Petrolera | Home win (outsider), market odds: 4.68 | Alianza Petrolera vs Millonarios: 2FTFinished4HT 2–3 | Away win (favourite), market odds: 1.76 |  Millonariosposition 7 | |
| 22:00 | position 5Independiente Santa Fe | Home win (favourite), market odds: 2.55 | Independiente Santa Fe vs Once Caldas: 2FTFinished1HT 1–1 | Away win (outsider), market odds: 3.30 |  Once Caldasposition 8 | |
| 22:00 | position 4Atlético Bucaramanga | Home win (favourite), market odds: 2.49 | Atlético Bucaramanga vs Deportivo Pereira: 1FTFinished3HT 0–0 | Away win (outsider), market odds: 3.02 |  Deportivo Pereiraposition 17 | |
| 22:00 | position 1Atlético Nacional | Home win (favourite), market odds: 1.45 | Atlético Nacional vs La Equidad: 1FTFinished1HT 1–0 | Away win (outsider), market odds: 7.65 |  La Equidadposition 13 | |
| 22:00 | Unión Magdalena | Home win (outsider), market odds: 2.94 | Unión Magdalena vs América de Cali: 0FTFinished0HT 0–0 | Away win (favourite), market odds: 2.72 |  América de Caliposition 2 | |
| 22:00 | position 19Jaguares de Córdoba | Home win (outsider), market odds: 6.51 | Jaguares de Córdoba vs Junior: 0FTFinished2HT 0–0 | Away win (favourite), market odds: 1.65 |  Juniorposition 14 | |
| 22:00 | position 18Deportivo Pasto | Home win (favourite), market odds: 2.47 | Deportivo Pasto vs Independiente Medellín: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 3.39 |  Independiente Medellínposition 6 | |
| 22:00 | Cortuluá | Home win (outsider), market odds: 8.82 | Cortuluá vs Águilas Doradas: 0FTFinished0HT 0–0 | Away win (favourite), market odds: 1.36 |  Águilas Doradasposition 10 | |
22:00 | position 6Sport Sébaco | —No pre-match price | Sport Sébaco vs Deportivo Ocotal: 2FTFinished0HT 0–0 | —No pre-match price |  Deportivo Ocotal | |
22:00 | Devonshire Cougars | —No pre-match price | Devonshire Cougars vs St. George's Colts: 2FTFinished1 | —No pre-match price |  St. George's Colts | |
22:00 | Chattanooga | Home win (favourite), market odds: 1.88 | Chattanooga vs Michigan Stars: 0FTFinished1HT 0–0 | Away win (outsider), market odds: 4.31 |  Michigan Stars | |
22:00 | position 4Águila | Home win (favourite), market odds: 1.39 | Águila vs Atlético Marte: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 6.30 |  Atlético Marte | |
| 22:00 | position 2FAS | Home win (favourite), market odds: 1.86 | FAS vs Dragón: 3FTFinished1HT 1–0 | Away win (outsider), market odds: 4.86 |  Dragón | |
| 22:00 | Jocoro | Home win (favourite), market odds: 2.26 | Jocoro vs Isidro Metapán: 0PenAfter Pen.0HT 0–0 | Away win (outsider), market odds: 3.54 |  Isidro Metapánposition 3 | |
22:00 | Aurora | —No pre-match price | Aurora vs Suchitepéquez: 3AETAfter ET2HT 0–0 | —No pre-match price |  Suchitepéquez | |
22:05 | position 15Defensores de Belgrano | Home win (outsider), market odds: 3.49 | Defensores de Belgrano vs Instituto: 0FTFinished0HT 0–0 | Away win (favourite), market odds: 2.63 |  Instituto | |
22:15 | position 13Real Tomayapo | Home win (favourite), market odds: 2.28 | Real Tomayapo vs Guabirá: CancCancelled | Away win (outsider), market odds: 3.05 |  Guabiráposition 8 | |
| 22:15 | position 7Alianza | Home win (favourite), market odds: 1.69 | Alianza vs Platense: 0FTFinished1HT 0–1 | Away win (outsider), market odds: 5.26 |  Platense | |
22:30 | Altitude | —No pre-match price | Altitude vs Port Layola: 2FTFinished1 | —No pre-match price |  Port Layola | |
| 22:30 | Progresso | —No pre-match price | Progresso vs San Pedro Pirates: 2FTFinished2 | —No pre-match price |  San Pedro Pirates | |
Oriente Petroleroposition 4