22:00 | position 14Humble Lions | Home win (favourite), market odds: 1.35 | Humble Lions vs Chapelton: 4FTFinished0HT 0–0 | Away win (outsider), market odds: 8.03 |  Chapeltonposition 10 | |
| 22:00 | Vere United | Home win (outsider), market odds: 5.22 | Vere United vs Mount Pleasant Academy: 0FTFinished5HT 0–2 | Away win (favourite), market odds: 1.61 |  Mount Pleasant Academyposition 5 | |
| 22:00 | position 9Cavalier | Home win (favourite), market odds: 2.23 | Cavalier vs Portmore United: 2FTFinished0HT 1–0 | Away win (outsider), market odds: 3.32 |  Portmore Unitedposition 8 | |
| 22:00 | position 4Montego Bay United | Home win (favourite), market odds: 1.78 | Montego Bay United vs Faulkland: 1FTFinished1HT 2–0 | Away win (outsider), market odds: 4.02 |  Faulkland | |
22:00 | position 9San Martín San Juan | Home win (favourite), market odds: 2.14 | San Martín San Juan vs Temperley: 3FTFinished1HT 1–0 | Away win (outsider), market odds: 4.08 |  Temperleyposition 3 | |
22:00 | Valledupar | Home win (favourite), market odds: 1.59 | Valledupar vs Bogotá: 0FTFinished2HT 0–1 | Away win (outsider), market odds: 6.76 |  Bogotáposition 10 | |
22:00 | position 2Caracas | Home win (favourite), market odds: 1.32 | Caracas vs Mineros de Guayana: 1FTFinished1HT 1–1 | Away win (outsider), market odds: 7.40 |  Mineros de Guayana | |
22:00 | Empire Club | —No pre-match price | Empire Club vs Deacons: 4FTFinished4 | —No pre-match price |  Deacons | |
22:00 | Defence Force | —No pre-match price | Defence Force vs Cunupia: 1FTFinished0HT 0–0 | —No pre-match price |  Cunupia | |
22:00 | Blue Devils | —No pre-match price | Blue Devils vs Guelph United: 2FTFinished2 | —No pre-match price |  Guelph United | |
22:00 | Academia Anzoátegui | —No pre-match price | Academia Anzoátegui vs Fundación AIFI: 1FTFinished0HT 1–0 | —No pre-match price |  Fundación AIFI | |
| 22:00 | position 9Real Frontera | Home win (outsider), market odds: 3.21 | Real Frontera vs Yaracuyanos: 2FTFinished1HT 0–0 | Away win (favourite), market odds: 2.12 |  Yaracuyanosposition 3 | |
| 22:00 | Héroes de Falcón | —No pre-match price | Héroes de Falcón vs Ureña: 2FTFinished1HT 0–0 | —No pre-match price |  Ureñaposition 4 | |
22:00 | position 4Comerciantes | —No pre-match price | Comerciantes vs Unión Huaral: 0FTFinished0HT 0–0 | —No pre-match price |  Unión Huaral | |
| 22:00 | position 2Deportivo Llacuabamba | Home win (favourite), market odds: 2.41 | Deportivo Llacuabamba vs Alfonso Ugarte Puno: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 3.04 |  Alfonso Ugarte Puno | |
22:00 | Independência | Home win (favourite), market odds: 1.65 | Independência vs Atlético Acreano: 1FTFinished3HT 1–1 | Away win (outsider), market odds: 4.33 |  Atlético Acreano | |
| 22:15 | position 12Atlético | Home win (favourite), market odds: 1.84 | Atlético vs Barranquilla: 0FTFinished3HT 0–0 | Away win (outsider), market odds: 4.49 |  Barranquillaposition 15 | |
22:15 | Boyacá Chicó | —No pre-match price | Boyacá Chicó vs Independiente Medellín: 2FTFinished0HT 1–0 | —No pre-match price |  Independiente Medellín | |
22:30 | position 11LA Galaxy | Home win (outsider), market odds: 3.12 | LA Galaxy vs Los Angeles: 2FTFinished3HT 1–1 | Away win (favourite), market odds: 2.21 |  Los Angelesposition 6 | |
22:30 | position 16ADT | Home win (favourite), market odds: 2.15 | ADT vs Cusco: 0FTFinished2HT 0–1 | Away win (outsider), market odds: 3.56 |  Cuscoposition 10 | |
22:30 | position 14Delfin | Home win (favourite), market odds: 1.88 | Delfin vs Mushuc Runa: 3FTFinished0HT 1–0 | Away win (outsider), market odds: 4.12 |  Mushuc Runaposition 12 | |
| 22:30 | position 3Real Cartagena | Home win (favourite), market odds: 2.39 | Real Cartagena vs Fortaleza CEIF: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 3.22 |  Fortaleza CEIF | |
| 22:30 | Los Chankas | Home win (favourite), market odds: 1.71 | Los Chankas vs Universidad San Martín: 2FTFinished0HT 1–0 | Away win (outsider), market odds: 4.32 |  Universidad San Martínposition 2 | |
| 22:30 | Comerciantes Unidos | Home win (favourite), market odds: 1.65 | Comerciantes Unidos vs Carlos Stein: 2FTFinished1HT 0–1 | Away win (outsider), market odds: 4.76 |  Carlos Stein | |
22:30 | Limón Black Star | Home win (outsider), market odds: 3.50 | Limón Black Star vs Jicaral: 2FTFinished1HT 0–0 | Away win (favourite), market odds: 1.94 |  Jicaralposition 1 | |
