22:00 | position 13Atlanta United | Home win (favourite), market odds: 2.55 | Atlanta United vs Philadelphia Union: 2FTFinished0HT 1–0 | Away win (outsider), market odds: 2.71 |  Philadelphia Unionposition 6 | |
22:00 | Colón | Home win (favourite), market odds: 2.74 | Colón vs Racing Club: 0FTFinished4HT 0–3 | Away win (outsider), market odds: 2.95 |  Racing Clubposition 11 | |
22:00 | position 3Deportivo La Guaira | Home win (outsider), market odds: 2.94 | Deportivo La Guaira vs Caracas: 2FTFinished1HT 2–1 | Away win (favourite), market odds: 2.50 |  Caracasposition 2 | |
22:00 | Deacons | —No pre-match price | Deacons vs Silver Sands: 2FTFinished1 | —No pre-match price |  Silver Sands | |
22:00 | position 49 de Octubre | Home win (favourite), market odds: 2.10 | 9 de Octubre vs Búhos ULVR: 1FTFinished1HT 1–0 | Away win (outsider), market odds: 3.75 |  Búhos ULVR | |
22:00 | Parnahyba | Home win (outsider), market odds: 3.00 | Parnahyba vs Maranhão: 0FTFinished3HT 0–1 | Away win (favourite), market odds: 2.36 |  Maranhão | |
22:00 | position 6Delfines Del Este | Home win (favourite), market odds: 1.84 | Delfines Del Este vs Jarabacoa: 3FTFinished1HT 2–1 | Away win (outsider), market odds: 3.38 |  Jarabacoaposition 7 | |
22:00 | position 4Comerciantes | Home win (favourite), market odds: 1.40 | Comerciantes vs Juan Aurich: 1FTFinished0HT 1–0 | Away win (outsider), market odds: 6.44 |  Juan Aurich | |
| 22:00 | Alfonso Ugarte Puno | Home win (favourite), market odds: 1.54 | Alfonso Ugarte Puno vs Santos: 1FTFinished1HT 0–1 | Away win (outsider), market odds: 4.97 |  Santosposition 1 | |
22:00 | Oly Town | —No pre-match price | Oly Town vs Capital: 0FTFinished3 | —No pre-match price |  Capital | |
22:00 | Estudiantes Río Cuarto | Home win (favourite), market odds: 2.08 | Estudiantes Río Cuarto vs Almagro: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 4.59 |  Almagroposition 15 | |
| 22:00 | position 16Patronato | Home win (favourite), market odds: 1.65 | Patronato vs Flandria: 3FTFinished1HT 2–0 | Away win (outsider), market odds: 6.06 |  Flandria | |
22:00 | Centro Caribe U22 | Home win (favourite), market odds: 1.58 | Centro Caribe U22 vs Jamaica U22: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 4.42 |  Jamaica U22 | |
| 22:10 | position 15Defensores de Belgrano | Home win (favourite), market odds: 2.52 | Defensores de Belgrano vs Agropecuario: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 3.29 |  Agropecuarioposition 12 | |
22:30 | position 11Atlético Grau | Home win (favourite), market odds: 1.41 | Atlético Grau vs Carlos Mannucci: 0FTFinished2HT 0–0 | Away win (outsider), market odds: 7.66 |  Carlos Mannucci | |
22:30 | position 5Vancouver FC | Home win (outsider), market odds: 3.99 | Vancouver FC vs York United: 1FTFinished2HT 1–1 | Away win (favourite), market odds: 1.82 |  York Unitedposition 6 | |
| 22:30 | Imbabura | Home win (favourite), market odds: 2.19 | Imbabura vs Independiente Juniors: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 3.40 |  Independiente Juniorsposition 3 | |
Cearáposition 16
Águia de Marabá
Aimoré
Windsor TFC
Mid Isle Mariners
Toledo Villa
Santosposition 9
Angel Cityposition 5