01:00 | position 4Universitario | —No pre-match price | Universitario vs Árabe Unido: 0FTFinished0HT 0–0 | —No pre-match price |  Árabe Unidoposition 2 | |
01:00 | position 3Belgrano | Home win (favourite), market odds: 2.91 | Belgrano vs Independiente: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 3.08 |  Independienteposition 7 | |
| 01:00 | position 1Tigre | Home win (favourite), market odds: 2.73 | Tigre vs Gimnasia La Plata: 1FTFinished1HT 0–1 | Away win (outsider), market odds: 2.91 |  Gimnasia La Plataposition 2 | |
01:00 | position 13Audax Italiano | Home win (favourite), market odds: 1.71 | Audax Italiano vs Cobreloa: 2FTFinished0HT 1–0 | Away win (outsider), market odds: 5.06 |  Cobreloa | |
01:00 | position 1Charlotte Independence | Home win (favourite), market odds: 1.96 | Charlotte Independence vs Richmond Kickers: 0FTFinished1HT 0–0 | Away win (outsider), market odds: 3.28 |  Richmond Kickersposition 17 | |
01:00 | position 3Detroit City | Home win (favourite), market odds: 2.67 | Detroit City vs New Mexico United: 1FTFinished0HT 1–0 | Away win (outsider), market odds: 2.77 |  New Mexico Unitedposition 1 | |
| 01:00 | position 10Loudoun United | Home win (favourite), market odds: 1.96 | Loudoun United vs Birmingham Legion: 4FTFinished2HT 0–1 | Away win (outsider), market odds: 3.60 |  Birmingham Legionposition 11 | |
| 01:00 | position 8Miami | Home win (outsider), market odds: 3.12 | Miami vs Hartford Athletic: 0FTFinished3HT 0–0 | Away win (favourite), market odds: 2.14 |  Hartford Athleticposition 6 | |
| 01:00 | position 9Indy Eleven | Home win (favourite), market odds: 1.88 | Indy Eleven vs El Paso Locomotive: 3FTFinished1HT 1–0 | Away win (outsider), market odds: 3.86 |  El Paso Locomotiveposition 3 | |
01:00 | position 6San Marcos | Home win (favourite), market odds: 2.43 | San Marcos vs La Serena: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 2.94 |  La Serena | |
01:00 | Tailevu Naitasiri | —No pre-match price | Tailevu Naitasiri vs Navua: 1FTFinished2 | —No pre-match price |  Navua | |
01:00 | Maryland Bobcats | Home win (favourite), market odds: 1.57 | Maryland Bobcats vs Michigan Stars: 3FTFinished1HT 2–1 | Away win (outsider), market odds: 4.75 |  Michigan Stars | |
01:00 | position 7Tampa Bay Sun | —No pre-match price | Tampa Bay Sun vs Brooklyn: 0FTFinished1HT 0–1 | —No pre-match price |  Brooklynposition 6 | |
01:00 | Mexicali FC | —No pre-match price | Mexicali FC vs Tritons Vallarta: 1FTFinished2HT 1–0 | —No pre-match price |  Tritons Vallarta | |
| 01:00 | position 4Mineros de Fresnillo | Home win (favourite), market odds: 1.62 | Mineros de Fresnillo vs Tigres de Álica: 0FTFinished1HT 0–1 | Away win (outsider), market odds: 4.80 |  Tigres de Álica | |
| 01:00 | UA Zacatecas | Home win (favourite), market odds: 1.62 | UA Zacatecas vs Real Apodaca: 3FTFinished1HT 2–1 | Away win (outsider), market odds: 4.00 |  Real Apodacaposition 9 | |
01:15 | Génesis | Home win (outsider), market odds: 3.04 | Génesis vs Motagua: 0FTFinished3HT 0–0 | Away win (favourite), market odds: 2.27 |  Motaguaposition 3 | |
01:30 | position 13Atlanta United | Home win (favourite), market odds: 1.72 | Atlanta United vs Nashville SC: 0FTFinished2HT 0–1 | Away win (outsider), market odds: 4.51 |  Nashville SCposition 1 | |
| 01:30 | position 9Cincinnati | Home win (favourite), market odds: 2.26 | Cincinnati vs Columbus Crew: 0FTFinished0HT 0–0 | Away win (outsider), market odds: 2.95 |  Columbus Crewposition 7 | |
| 01:30 | position 14D.C. United | Home win (favourite), market odds: 2.49 | D.C. United vs New York City: 1FTFinished1HT 0–1 | Away win (outsider), market odds: 2.76 |  New York Cityposition 11 | |
| 01:30 | position 2Inter Miami | Home win (favourite), market odds: 1.46 | Inter Miami vs Philadelphia Union: 3FTFinished1HT 2–1 | Away win (outsider), market odds: 6.15 |  Philadelphia Unionposition 6 | |
| 01:30 | position 15Montréal | Home win (outsider), market odds: 2.87 | Montréal vs Charlotte: 2FTFinished1HT 2–1 | Away win (favourite), market odds: 2.47 |  Charlotteposition 5 | |
| 01:30 | position 8Orlando City | Home win (favourite), market odds: 1.47 | Orlando City vs New England: 3FTFinished0HT 2–0 | Away win (outsider), market odds: 6.24 |  New Englandposition 3 | |
| 01:30 | position 12Toronto | Home win (favourite), market odds: 1.88 | Toronto vs Austin: 2FTFinished1HT 2–0 | Away win (outsider), market odds: 4.10 |  Austinposition 14 | |
| 01:30 | position 7Chattanooga Red Wolves | Home win (outsider), market odds: 3.26 | Chattanooga Red Wolves vs Greenville Triumph: 2FTFinished5HT 1–2 | Away win (favourite), market odds: 2.05 |  Greenville Triumphposition 15 | |
| 01:30 | position 1Tampa Bay Rowdies | Home win (favourite), market odds: 1.95 | Tampa Bay Rowdies vs Pittsburgh Riverhounds: 2FTFinished1HT 0–1 | Away win (outsider), market odds: 3.77 |  Pittsburgh Riverhoundsposition 5 | |
01:30 | position 15Racing Louisville | Home win (favourite), market odds: 1.86 | Racing Louisville vs Angel City: 2FTFinished1HT 1–1 | Away win (outsider), market odds: 3.70 |  Angel Cityposition 5 | |
01:30 | Sete | —No pre-match price | Sete vs Sul América: 2PenAfter Pen.2HT 0–0 | —No pre-match price |  Sul América | |
