01:00 | position 12Pachuca | Home win (favourite), market odds: 1.96 | Pachuca vs UNAM Pumas: 0FTFinished2HT 0–2 | Away win (outsider), market odds: 3.77 |  UNAM Pumasposition 10 | |
| 01:00 | position 15Tigres UANL | Home win (favourite), market odds: 1.21 | Tigres UANL vs Mazatlan FC: 5FTFinished1HT 1–0 | Away win (outsider), market odds: 12.27 |  Mazatlan FC | |
01:00 | position 6Libertad Asuncion | Home win (outsider), market odds: 4.03 | Libertad Asuncion vs Olimpia Asuncion: 3FTFinished2HT 2–0 | Away win (favourite), market odds: 2.03 |  Olimpia Asuncionposition 1 | |
01:00 | Brooklyn W | —No pre-match price | Brooklyn W vs Dallas Trinity W: 1FTFinished1HT 0–0 | —No pre-match price |  Dallas Trinity W | |
01:00 | position 6Santos Laguna W | Home win (favourite), market odds: 1.43 | Santos Laguna W vs Queretaro W: 3FTFinished0HT 1–0 | Away win (outsider), market odds: 5.89 |  Queretaro Wposition 8 | |
01:00 | St Andrew Lions | Home win (outsider), market odds: 11.90 | St Andrew Lions vs Paradise SC: 1FTFinished7HT 1–3 | Away win (favourite), market odds: 1.15 |  Paradise SC | |
01:00 | Grenades | —No pre-match price | Grenades vs Attacking Saints: 4FTFinished0HT 2–0 | —No pre-match price |  Attacking Saints | |
01:00 | Chattanooga Red Wolves | —No pre-match price | Chattanooga Red Wolves vs Corpus Christi FC: 0FTFinished1HT 0–1 | —No pre-match price |  Corpus Christi FC | |
| 01:00 | Hartford Athletic | Home win (favourite), market odds: 2.79 | Hartford Athletic vs Rhode Island: 0PenAfter Pen.0HT 0–0 | Away win (outsider), market odds: 2.81 |  Rhode Island | |
| 01:00 | Indy Eleven | —No pre-match price | Indy Eleven vs Union Omaha: 1FTFinished2HT 0–1 | —No pre-match price |  Union Omaha | |
| 01:00 | Lexington | —No pre-match price | Lexington vs Forward Madison: 4FTFinished2HT 1–1 | —No pre-match price |  Forward Madison | |
| 01:00 | Louisville City | —No pre-match price | Louisville City vs Fort Wayne: 3FTFinished1HT 1–1 | —No pre-match price |  Fort Wayne | |
| 01:00 | Pittsburgh | —No pre-match price | Pittsburgh vs Greenville: 3FTFinished0HT 2–0 | —No pre-match price |  Greenville | |
| 01:00 | Westchester SC | Home win (outsider), market odds: 3.41 | Westchester SC vs Portland Hearts of Pine: 2PenAfter Pen.2HT 1–1 | Away win (favourite), market odds: 1.93 |  Portland Hearts of Pine | |
01:10 | position 3Dep. Cali | Home win (favourite), market odds: 2.83 | Dep. Cali vs America De Cali: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 2.86 |  America De Caliposition 2 | |
01:30 | position 8Columbus Crew | Home win (favourite), market odds: 1.88 | Columbus Crew vs Philadelphia Union: 2FTFinished0HT 2–0 | Away win (outsider), market odds: 4.20 |  Philadelphia Unionposition 6 | |
| 01:30 | position 14DC United | Home win (favourite), market odds: 1.79 | DC United vs Orlando City: 3FTFinished2HT 1–0 | Away win (outsider), market odds: 4.63 |  Orlando Cityposition 9 | |
| 01:30 | position 7FC Cincinnati | Home win (favourite), market odds: 1.68 | FC Cincinnati vs New York Red Bulls: 2FTFinished0HT 2–0 | Away win (outsider), market odds: 4.51 |  New York Red Bullsposition 10 | |
| 01:30 | position 2Inter Miami | Home win (favourite), market odds: 1.47 | Inter Miami vs New England Revolution: 1FTFinished1HT 0–0 | Away win (outsider), market odds: 6.45 |  New England Revolutionposition 3 | |
01:30 | position 9Sport Recife | Home win (favourite), market odds: 2.48 | Sport Recife vs Novorizontino: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 3.13 |  Novorizontinoposition 1 | |
| 01:30 | Tampa Bay Sun W | —No pre-match price | Tampa Bay Sun W vs Carolina Ascent W: 1FTFinished2HT 0–0 | —No pre-match price |  Carolina Ascent W | |
01:30 | Guapore | Home win (favourite), market odds: 2.56 | Guapore vs Porto Velho: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 2.74 |  Porto Velho | |
01:30 | position 10Guabira | Home win (outsider), market odds: 2.55 | Guabira vs Always Ready: 1FTFinished2HT 0–0 | Away win (favourite), market odds: 2.40 |  Always Readyposition 2 | |
| 01:30 | Sporting Jax | —No pre-match price | Sporting Jax vs Miami FC: 0FTFinished1HT 0–1 | —No pre-match price |  Miami FC | |
| 01:30 | Tampa Bay | —No pre-match price | Tampa Bay vs Sarasota Paradise: 2FTFinished0HT 1–0 | —No pre-match price |  Sarasota Paradise | |
