21:00 | PSV | Home win (favourite), market odds: 1.24 | PSV vs Zürich: 5FTFinished0HT 3–0 | Away win (outsider), market odds: 11.69 |  Zürich | WWLWWDLDDL | 3.9 avg from 18 matches | 9.4 avg from 17 matches | 3.9 avg from 16 matches | |
| 21:00 | Ludogorets | Home win (favourite), market odds: 1.61 | Ludogorets vs HJK: 2FTFinished0HT 1–0 | Away win (outsider), market odds: 6.01 |  HJK | WDLDLWDWLW | 3.0 avg from 20 matches | 9.8 avg from 6 matches | 5.8 avg from 20 matches | |
| 21:00 | Union Berlin | Home win (favourite), market odds: 1.35 | Union Berlin vs Malmö: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 10.19 |  Malmö | WWLWLDLDWL | 2.5 avg from 19 matches | 9.4 avg from 18 matches | 4.3 avg from 17 matches | |
| 21:00 | Manchester United | Home win (favourite), market odds: 1.06 | Manchester United vs Omonia Nicosia: 1FTFinished0HT 0–0 | Away win (outsider), market odds: 42.61 |  Omonia Nicosiaposition 18 | WWLWLLLWWL | 3.1 avg from 17 matches | 7.3 avg from 11 matches | 4.1 avg from 17 matches | |
| 21:00 | position 20Real Sociedad | Home win (favourite), market odds: 1.31 | Real Sociedad vs Sheriff: 3FTFinished0HT 1–0 | Away win (outsider), market odds: 13.06 |  Sheriff | WWWWWWLWDL | 2.3 avg from 18 matches | 7.5 avg from 12 matches | 4.4 avg from 18 matches | |
| 21:00 | Lazio | Home win (favourite), market odds: 1.52 | Lazio vs Sturm Graz: 2FTFinished2HT 1–0 | Away win (outsider), market odds: 6.39 |  Sturm Grazposition 24 | WDWWLWDWWW | 3.1 avg from 19 matches | 10.5 avg from 17 matches | 3.8 avg from 18 matches | |
| 21:00 | Trabzonspor | Home win (outsider), market odds: 4.45 | Trabzonspor vs Monaco: 4FTFinished0HT 1–0 | Away win (favourite), market odds: 1.83 |  Monaco | DLWWWWWWLW | 3.0 avg from 19 matches | 10.2 avg from 18 matches | 4.4 avg from 18 matches | |
| 21:00 | position 3Ferencvaros | Home win (favourite), market odds: 2.69 | Ferencvaros vs Red Star Belgrade: 2FTFinished1HT 1–0 | Away win (outsider), market odds: 2.71 |  Red Star Belgrade | WLLWWWWWWW | 2.9 avg from 20 matches | 10.0 avg from 6 matches | 5.2 avg from 19 matches | |
21:00 | FCSB | Home win (outsider), market odds: 2.96 | FCSB vs Silkeborg: 0FTFinished5HT 0–2 | Away win (favourite), market odds: 2.41 |  Silkeborg | WLWLDDWWWL | 3.1 avg from 19 matches | 9.0 avg from 12 matches | 3.7 avg from 18 matches | |
| 21:00 | West Ham United | Home win (favourite), market odds: 1.61 | West Ham United vs Anderlecht: 2FTFinished1HT 2–0 | Away win (outsider), market odds: 5.95 |  Anderlecht | WWWLWWLLWD | 2.4 avg from 19 matches | 10.9 avg from 19 matches | 4.5 avg from 19 matches | |
| 21:00 | Hapoel Be'er Sheva | Home win (favourite), market odds: 2.57 | Hapoel Be'er Sheva vs Lech Poznań: 1FTFinished1HT 1–1 | Away win (outsider), market odds: 2.92 |  Lech Poznań | DDWWLWDDWW | 2.5 avg from 20 matches | 7.6 avg from 13 matches | 5.2 avg from 19 matches | |
| 21:00 | Nice | Home win (favourite), market odds: 1.43 | Nice vs Slovacko: 1FTFinished2HT 1–0 | Away win (outsider), market odds: 8.94 |  Slovacko | WWLLDLLWLL | 2.8 avg from 20 matches | 9.0 avg from 13 matches | 3.6 avg from 19 matches | |
| 21:00 | Vaduz | Home win (outsider), market odds: 4.47 | Vaduz vs Dnipro-1: 1FTFinished2HT 1–1 | Away win (favourite), market odds: 1.84 |  Dnipro-1 | DDLWLWDWWW | 4.0 avg from 18 matches | 9.5 avg from 6 matches | 4.6 avg from 16 matches | |
| 21:00 | Shamrock Rovers | Home win (outsider), market odds: 5.66 | Shamrock Rovers vs Molde: 0FTFinished2HT 0–1 | Away win (favourite), market odds: 1.63 |  Molde | WLWWDWWWWL | 3.1 avg from 19 matches | 10.0 avg from 12 matches | 4.8 avg from 17 matches | |
| 21:00 | Ballkani | Home win (outsider), market odds: 2.73 | Ballkani vs Sivasspor: 1FTFinished2HT 1–0 | Away win (favourite), market odds: 2.64 |  Sivasspor | WWWWWWLLWL | 2.9 avg from 20 matches | 10.8 avg from 12 matches | 4.8 avg from 12 matches | |
| 21:00 | Zalgiris | Home win (favourite), market odds: 1.97 | Zalgiris vs Pyunik: 2FTFinished1HT 2–0 | Away win (outsider), market odds: 4.34 |  Pyunik | WLDWWLWWLW | 2.5 avg from 19 matches | 7.0 avg from 6 matches | 4.0 avg from 19 matches | |
21:00 | position 5Granada | Home win (favourite), market odds: 2.09 | Granada vs Sporting Gijon: 5FTFinished0HT 2–0 | Away win (outsider), market odds: 4.03 |  Sporting Gijonposition 7 | DDLWLWDWLL | 2.1 avg from 14 matches | 9.8 avg from 14 matches | 4.8 avg from 13 matches | |
21:00 | position 4Oriente Petrolero | Home win (favourite), market odds: 1.53 | Oriente Petrolero vs Independiente: 3FTFinished3HT 1–2 | Away win (outsider), market odds: 6.11 |  Independiente | LWWLWDLDLW | 2.4 avg from 18 matches | —Corners: only 0 of 18 matches have it, need 6 | 6.2 avg from 18 matches | |
21:30 | position 4Vélez Sarsfield | Home win (favourite), market odds: 2.30 | Vélez Sarsfield vs Talleres de Córdoba: 2FTFinished1HT 0–0 | Away win (outsider), market odds: 3.88 |  Talleres de Córdobaposition 3 | LWLWLWLLDW | 1.8 avg from 20 matches | 7.9 avg from 17 matches | 5.8 avg from 20 matches | |
Liverpoolposition 4
Vichttalposition 7
Sol de América
Boca Juniors
Always Ready
Alianza Petroleraposition 16
Dragón